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The second mechanism is a temporary increase in serum-ascorbic acid levels that exerts its own protective effect through inhibition of platelet activation ([@B27], [@B28]) and oxidant stress ([@B29], [@B30]). Again, there are now several studies showing that higher serum levels of ascorbic acid are associated with lower mortality in patients with ACS and in patients that received angioplasty ([@B31], [@B32]). Interestingly, in our study we found that the positive effect of intravenous lisofylline was restricted to the subpopulation of patients that had undergone coronary angiography and that were therefore likely to have had angioplasty ([Supplemental Table 6](#sd){ref-type=”supplementary-material”}).

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